Burns Christopher M
Section of Rheumatology, Department of Medicine, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Rheumatology 5C, One Medical Center Drive, Lebanon, NH 03756, USA.
Rheum Dis Clin North Am. 2016 Feb;42(1):1-14, vii. doi: 10.1016/j.rdc.2015.08.001.
Philip Hench, Edward Kendall, and Tadeus Reichstein received the Nobel Prize in medicine and physiology in 1950 for their "investigations of the hormones of the adrenal cortex." Hench and Kendall took compound E from the laboratory to the clinic to the Nobel Prize in a span of 2 years. This article examines the paths that led to the day when the first rheumatoid arthritis patient received cortisone, and from there to the 1950 Nobel Prize ceremony. The aftermath of this achievement is also discussed. Although there have been significant advances in corticosteroid preparations and use since 1950, the side effects remain daunting.
菲利普·亨奇、爱德华·肯德尔和塔德乌什·赖希施泰因因“对肾上腺皮质激素的研究”于1950年获得诺贝尔医学与生理学奖。亨奇和肯德尔在短短两年内，就将化合物E从实验室带到临床，再到荣获诺贝尔奖。本文探讨了首位类风湿性关节炎患者接受可的松治疗这一事件的发展历程，以及此后直至1950年诺贝尔奖颁奖典礼的相关情况。此外，还讨论了这一成就带来的后续影响。尽管自1950年以来，皮质类固醇制剂及其应用有了显著进展，但副作用依然令人望而生畏。
