Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Sydney, Australia.
Int Psychogeriatr. 2010 Mar;22(2):300-5. doi: 10.1017/S1041610209991220. Epub 2009 Nov 12.
There is a growing body of research exploring differences in behavioral and psychological symptoms of dementia (BPSD) between Alzheimer's disease (AD) and vascular dementia (VaD), yet these differences are inconsistent and it is uncertain whether this inconsistency might be due to the confounding effect of differing severities of dementia.
BPSD, measured with the Behavior Problems Check List (BPCL) and Revised Memory and Behavior Problems Check List (RMBPCL) and CDR-measured severity of dementia were examined using archival data of individuals with AD (N = 377) or VaD (including multi-infarct and other vascular causes; N = 74) presenting to a Sydney memory disorders clinic over a 20-year period.
There was no significant difference in scores for AD and VaD patients on the BPCL or on the RMBPCL when controlling for sex and severity of dementia. However, severity of BPSD increased with increasing severity of dementia.
BPSD severity is no different in AD and VaD at the time of initial assessment in a memory disorders clinic population of mild to moderate dementia. However, BPSD increases with severity of dementia in this group.
越来越多的研究探索了阿尔茨海默病（AD）和血管性痴呆（VaD）患者的行为和心理症状的差异，但这些差异并不一致，尚不确定这种不一致是否是由于痴呆严重程度的混杂影响。
使用行为问题检查表（BPCL）和修订后的记忆和行为问题检查表（RMBPCL）以及 CDR 测量的痴呆严重程度，对在 20 年期间在悉尼记忆障碍诊所就诊的 AD（N=377）或 VaD（包括多发梗死和其他血管原因；N=74）患者的档案数据进行了检查。
在控制性别和痴呆严重程度后，AD 和 VaD 患者的 BPCL 或 RMBPCL 评分没有显著差异。然而，随着痴呆严重程度的增加，BPSD 的严重程度也随之增加。
在轻度至中度痴呆的记忆障碍诊所人群中，初始评估时 AD 和 VaD 的 BPSD 严重程度没有差异。然而，在该人群中，BPSD 随痴呆严重程度的增加而增加。
