Institute of Molecular and Cellular Biology, 61, Biopolis Drive, Proteos, Singapore.
Curr Biol. 2009 Sep 15;19(17):R729-31. doi: 10.1016/j.cub.2009.07.060.
Recent reports examining the mammalian kinesin relative Kif7 highlight the conserved role for microtubule motor proteins in Drosophila and vertebrate Hedgehog signalling. Mammalian Kif7 action centres at the primary cilium, an organelle absent from Drosophila. These studies raise interesting questions about the coupling of microtubule trafficking to the Hedgehog pathway.
最近的研究报告检查了哺乳动物的驱动蛋白相关蛋白 Kif7，突出了微管马达蛋白在果蝇和脊椎动物 Hedgehog 信号通路中的保守作用。哺乳动物的 Kif7 作用中心位于初级纤毛，这是一种果蝇中不存在的细胞器。这些研究提出了关于微管运输与 Hedgehog 途径偶联的有趣问题。
