Kif7 保持纤毛尖端的形状。
Kif7 keeps cilia tips in shape.
机构信息
Department of Biology, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen OE, Denmark.
Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
出版信息
Nat Cell Biol. 2014 Jul;16(7):623-5. doi: 10.1038/ncb2997.
The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. Kif7 is now found to inhibit microtubule growth to restrict and coordinate the length of axonemal microtubules at the ciliary tip. Such Kif7-mediated organization of the ciliary tip compartment regulates Gli activity and is proposed to be required for correct Hedgehog signalling.
驱动蛋白-4 型 motor 蛋白 Kif7 通过控制 Gli 转录因子的活性来调节哺乳动物纤毛中的 Hedgehog 信号通路。现在发现 Kif7 抑制微管生长，以限制和协调纤毛尖端的轴丝微管的长度。这种 Kif7 介导的纤毛尖端隔室的组织调节 Gli 活性，并被提议是正确的 Hedgehog 信号所必需的。
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