Giordano Thomas P, Hartman Christine, Gifford Allen L, Backus Lisa I, Morgan Robert O
Baylor College of Medicine, Houston, Texas, USA.
HIV Clin Trials. 2009 Sep-Oct;10(5):299-305. doi: 10.1310/hct1005-299.
Poor retention in HIV care leads to poor survival. The predictors of poor retention in HIV care are not well understood, especially from US nationwide datasets. We determined the predictors of poor retention in HIV care among a group of US veterans and examined whether poor retention was confounded by other predictors of survival.
We conducted a retrospective cohort study of 2,619 male US veterans who started antiretroviral therapy after January 1, 1998. Poor retention in HIV care was defined as having had at least 1 quarter-year without any primary care visit in the year after starting antiretroviral therapy. Survival was assessed through 2002. Logistic regression and Cox models were constructed.
Thirty-six percent of patients had poor retention in care. In multivariable analysis, younger age, Black race/ethnicity, CD4 cell count >350 x10(6)/L, hepatitis C infection, and illicit drug use were predictive of poor retention in care. Having a chronic medical comorbidity and being identified as a man having sex with men (MSM) were associated with improved retention in care. In multivariable survival analyses, poor retention in care was not a confounder or moderator for other variables that predicted survival.
Retention in HIV care is an independent predictor of survival. As routine HIV screening increases, more people with the characteristics predictive of poor retention in care will be identified. Interventions to improve retention in care are needed.
艾滋病护理留存率低会导致生存率降低。目前对于艾滋病护理留存率低的预测因素尚不清楚,尤其是来自美国全国数据集的情况。我们确定了一组美国退伍军人中艾滋病护理留存率低的预测因素,并研究了留存率低是否会被其他生存预测因素混淆。
我们对1998年1月1日之后开始抗逆转录病毒治疗的2619名美国男性退伍军人进行了一项回顾性队列研究。艾滋病护理留存率低被定义为在开始抗逆转录病毒治疗后的一年内至少有一个季度没有进行任何初级保健就诊。通过2002年评估生存率。构建了逻辑回归模型和Cox模型。
36%的患者护理留存率低。在多变量分析中,年龄较小、黑人种族/族裔、CD4细胞计数>350×10(6)/L、丙型肝炎感染和使用非法药物是护理留存率低的预测因素。患有慢性合并症以及被认定为男男性行为者(MSM)与护理留存率提高相关。在多变量生存分析中,护理留存率低不是其他预测生存的变量的混杂因素或调节因素。
艾滋病护理留存率是生存的独立预测因素。随着常规艾滋病筛查的增加,将识别出更多具有护理留存率低预测特征的人。需要采取干预措施来提高护理留存率。