主观临床脂肪萎缩评估与双能X线吸收法测量的肢体脂肪相关。

Subjective clinical lipoatrophy assessment correlates with DEXA-measured limb fat.

作者信息

Tungsiripat Marisa, O'Riordan Mary Ann, Storer Norma, Harrill Danielle, Ganz Jason, Libutti Daniel, Gerschenson Mariana, McComsey Grace A

机构信息

Department of Infectious Diseases, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

出版信息

HIV Clin Trials. 2009 Sep-Oct;10(5):314-9. doi: 10.1310/hct1005-314.

DOI:10.1310/hct1005-314

PMID:19906628

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2783162/

Abstract

OBJECTIVES

Although physician- and patient-rated diagnoses of lipoatrophy are currently used as a basis for inclusion into clinical trials, few studies have compared physician- or patient-rated lipoatrophy severity with objective measures. We aim to assess the validity of physician- and patient-rated diagnoses of lipoatrophy by evaluating the correlation between clinical assessments of lipoatrophy and objective fat indices.

METHODS

This cross-sectional study evaluated the association between clinical lipoatrophy scores and DEXA-measured limb fat (n = 154) and subcutaneous fat mitochondrial DNA (mtDNA) levels (n = 80) in HIV+ individuals.

RESULTS

There was a significant negative correlation between DEXA-measured limb fat and lipoatrophy scores generated by either the patients (r = -0.27, p = .008) or the physician (r = -0.48, p < .0001). Also, a significant positive correlation was found between the patient-generated lipoatrophy score and the physician score (r = 0.68, p < .0001). However, there was no correlation between fat mtDNA levels and DEXA-measured limb fat (r = -0.09, p = .42) or between physician- or patient-generated lipoatrophy scores (r = -0.09, p = .43, and r = 0.04, p = .71, respectively).

CONCLUSION

These results suggest that physician- and patient-rated lipoatrophy scores may be useful surrogates for more expensive measures of lipoatrophy, which could be reserved for research studies.

摘要

目的

虽然目前医生和患者评定的脂肪萎缩诊断结果被用作纳入临床试验的依据，但很少有研究将医生或患者评定的脂肪萎缩严重程度与客观测量指标进行比较。我们旨在通过评估脂肪萎缩的临床评估与客观脂肪指数之间的相关性，来评估医生和患者评定的脂肪萎缩诊断的有效性。

方法

这项横断面研究评估了HIV阳性个体中临床脂肪萎缩评分与双能X线吸收法（DEXA）测量的肢体脂肪（n = 154）和皮下脂肪线粒体DNA（mtDNA）水平（n = 80）之间的关联。

结果

DEXA测量的肢体脂肪与患者（r = -0.27，p = 0.008）或医生（r = -0.48，p < 0.0001）得出的脂肪萎缩评分之间存在显著负相关。此外，患者得出的脂肪萎缩评分与医生评分之间存在显著正相关（r = 0.68，p < 0.0001）。然而，脂肪mtDNA水平与DEXA测量的肢体脂肪之间无相关性（r = -0.09，p = 0.42），医生或患者得出的脂肪萎缩评分之间也无相关性（分别为r = -0.09，p = 0.43和r = 0.04，p = 0.71）。