Hutchings Andrew, Durand Mary Alison, Grieve Richard, Harrison David, Rowan Kathy, Green Judith, Cairns John, Black Nick
Health Services Research Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT.
BMJ. 2009 Nov 11;339:b4353. doi: 10.1136/bmj.b4353.
To evaluate the impact and cost effectiveness of a programme to transform adult critical care throughout England initiated in late 2000.
Evaluation of trends in inputs, processes, and outcomes during 1998-2000 compared with last quarter of 2000-6.
96 critical care units in England.
349,817 admissions to critical care units.
Adoption of key elements of modernisation and increases in capacity. Units were categorised according to when they adopted key elements of modernisation and increases in capacity.
Trends in inputs (beds, costs), processes (transfers between units, discharge practices, length of stay, readmissions), and outcomes (unit and hospital mortality), with adjustment for case mix. Differences in annual costs and quality adjusted life years (QALYs) adjusted for case mix were used to calculate net monetary benefits (valuing a QALY gain at pound20,000 ($33,170, euro22 100)). The incremental net monetary benefits were reported as the difference in net monetary benefits after versus before 2000.
In the six years after 2000, the risk of unit mortality adjusted for case mix fell by 11.3% and hospital mortality by 13.4% compared with the steady state in the three preceding years. This was accompanied by substantial reductions both in transfers between units and in unplanned night discharges. The mean annual net monetary benefit increased significantly after 2000 (from pound402 ($667, euro445) to pound1096 ($1810, euro1210)), indicating that the changes were relatively cost effective. The relative contribution of the different initiatives to these improvements is unclear.
Substantial improvements in NHS critical care have occurred in England since 2000. While it is unclear which factors were responsible, collectively the interventions represented a highly cost effective use of NHS resources.
评估2000年末在英格兰启动的一项旨在变革成人重症监护的计划的影响和成本效益。
对1998 - 2000年期间与2000年最后一个季度至2006年最后一个季度的投入、过程和结果趋势进行评估。
英格兰的96个重症监护病房。
349817例入住重症监护病房的患者。
采用现代化的关键要素并增加容量。各病房根据采用现代化关键要素和增加容量的时间进行分类。
投入(床位、成本)、过程(病房之间的转院、出院方式、住院时间、再入院)和结局(病房和医院死亡率)的趋势,并对病例组合进行调整。针对病例组合调整后的年度成本和质量调整生命年(QALY)差异用于计算净货币效益(将一个QALY增益价值设定为2000英镑(33170美元,22100欧元))。增量净货币效益报告为2000年之后与之前净货币效益的差值。
与之前三年的稳定状态相比,2000年之后的六年里,经病例组合调整后的病房死亡率风险下降了11.3%,医院死亡率下降了13.4%。同时,病房之间的转院和非计划夜间出院也大幅减少。2000年之后,平均年度净货币效益显著增加(从402英镑(667美元,445欧元)增至1096英镑(1810美元,1210欧元)),表明这些变化具有相对成本效益。不同举措对这些改善的相对贡献尚不清楚。
自2000年以来,英格兰国民健康服务体系(NHS)的重症监护有了显著改善。虽然不清楚哪些因素起了作用,但总体而言,这些干预措施代表了对NHS资源的高效成本利用。