Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Am J Clin Nutr. 2010 Jan;91(1):131-9. doi: 10.3945/ajcn.2009.28097. Epub 2009 Nov 11.
Calcium supplementation has been suggested to have beneficial effects on serum lipids, blood pressure, and body weight, but these possibilities have not been rigorously assessed in men.
This study evaluated the effect of calcium supplementation on the change in the ratio of HDL to LDL cholesterol (primary endpoint) and on changes in cholesterol fractions, triglycerides, blood pressure, and body composition (secondary endpoints).
We carried out a randomized controlled trial of calcium supplementation in 323 generally healthy men over a period of 2 y. Subjects were randomly assigned to take placebo, 600 mg Ca/d, or 1200 mg Ca/d.
There was no significant treatment effect on the ratio of HDL to LDL cholesterol (P = 0.47) nor on weight, fat mass, lean mass, triglycerides, or total, LDL, or HDL cholesterol (P > 0.28 for all). There were downward trends in systolic and diastolic blood pressures within the calcium-supplemented groups, but there were no significant treatment effects over the whole trial period (P > 0.60). In a post hoc analysis of those with baseline calcium intakes below the median value (785 mg/d), blood pressures showed borderline treatment effects (P = 0.05-0.06 for changes at 2 y in those who received 1200 mg Ca/d compared with placebo: systolic, -4.2 mm Hg; diastolic, -3.3 mm Hg). Low magnesium intake showed a similar interaction. No treatment effects on weight or body composition were found.
These data do not show significant effects of calcium supplementation on serum lipids or body composition. Calcium supplementation in those with low dietary intakes may benefit blood pressure control. This trial was registered with the Australian Clinical Trials Registry as ACTRN 012605000274673.
补钙被认为对血清脂质、血压和体重有有益影响，但这些可能性尚未在男性中得到严格评估。
本研究评估了补钙对高密度脂蛋白与低密度脂蛋白胆固醇比值变化的影响（主要终点）以及胆固醇各组分、甘油三酯、血压和身体成分变化（次要终点）。
我们对 323 名一般健康男性进行了为期 2 年的补钙随机对照试验。受试者被随机分配服用安慰剂、600mg 钙/天或 1200mg 钙/天。
高密度脂蛋白与低密度脂蛋白胆固醇比值无显著治疗作用（P=0.47），体重、体脂、瘦体重、甘油三酯或总胆固醇、低密度脂蛋白胆固醇或高密度脂蛋白胆固醇也无显著变化（所有 P>0.28）。补钙组收缩压和舒张压呈下降趋势，但整个试验期间无显著治疗作用（P>0.60）。在基线钙摄入量低于中位数（785mg/天）的亚组分析中，血压显示出有边缘意义的治疗效果（服用 1200mg 钙/天与安慰剂相比，收缩压下降 4.2mmHg，舒张压下降 3.3mmHg，P=0.05-0.06）。低镁摄入量也显示出类似的相互作用。体重或身体成分无治疗作用。
这些数据并未显示补钙对血清脂质或身体成分有显著影响。对于低膳食摄入量的人，补钙可能有益于血压控制。本试验在澳大利亚临床试验注册处注册，注册号为 ACTRN 012605000274673。
