Islam Md Zahirul, Shamim Abu Ahmed, Akhtaruzzaman Mohammad, Kärkkäinen Merja, Lamberg-Allardt Christel
J Health Popul Nutr. 2014 Dec;32(4):687-95.
Elevated total cholesterol and low-density lipoprotein cholesterol in sera are both well-known risk factors of coronary heart disease. Adequate vitamin D status is important for optimal function of many organs and tissues of our body. There is continuing controversy about the effect of adequate vitamin D consumption on serum lipids and lipoproteins. The present study assessed the effect of vitamin D, calcium and multiple micronutrients supplementation on the lipid profile in Bangladeshi young female garment factory workers who have hypovitaminosis D. This placebo-controlled intervention trial conducted over a period of one year randomly assigned a total of 200 apparently healthy subjects aged 16-36 years to 4 groups. The subjects received daily supplements of 400 IU of vitamin D (VD group) or 400 IU of vitamin D+600 mg of calcium lactate (VD-Ca group), or multiple micronutrients with 400 IU of vitamin-D+600 mg of calcium lactate (MMN-VD-Ca group), or the group consuming placebo (PL group). Serum concentrations of lipid and lipoprotein, 25-hydroxyvitamin D (25OHD) and intact parathyroid hormone (iPTH) were measured at baseline and after one year of follow-up. No significant changes in the serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL-C/HDL-C ratio were observed in the supplemented groups compared to the placebo group. Supplementation had a positive effect (p<0.05) on very low-density-lipoprotein cholesterol (VLDL-C) and triacylglycerol (TAG). A negative correlation between changes in serum iPTH and HDL-C was observed, which indicated that subjects with the greatest decline in S-iPTH had the greatest increase in HDL-C. The results suggest that consumption of adequate vitamin D with calcium or MMN for one-year may have no impact on serum lipid profile in the subjects studied. Longer-term clinical trials with different doses of supplemental vitamin D are warranted in evaluating the effect of intervention.
血清中总胆固醇和低密度脂蛋白胆固醇升高均是冠心病众所周知的危险因素。充足的维生素D状态对于我们身体许多器官和组织的最佳功能很重要。关于充足的维生素D摄入对血脂和脂蛋白的影响一直存在争议。本研究评估了维生素D、钙和多种微量营养素补充剂对患有维生素D缺乏症的孟加拉年轻女性服装厂工人血脂谱的影响。这项为期一年的安慰剂对照干预试验将总共200名年龄在16至36岁之间的明显健康受试者随机分为4组。受试者每日补充400 IU维生素D（VD组）或400 IU维生素D + 600 mg乳酸钙（VD-Ca组），或含400 IU维生素D + 600 mg乳酸钙的多种微量营养素（MMN-VD-Ca组），或服用安慰剂的组（PL组）。在基线和随访一年后测量血脂和脂蛋白、25-羟基维生素D（25OHD）和完整甲状旁腺激素（iPTH）的血清浓度。与安慰剂组相比，补充组的血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、LDL-C/HDL-C比值水平无显著变化。补充剂对极低密度脂蛋白胆固醇（VLDL-C）和甘油三酯（TAG）有积极影响（p<0.05）。观察到血清iPTH变化与HDL-C之间存在负相关，这表明血清iPTH下降最大的受试者HDL-C升高最大。结果表明，在本研究对象中，一年中摄入充足的维生素D并同时补充钙或多种微量营养素可能对血脂谱没有影响。有必要进行不同剂量补充维生素D的长期临床试验来评估干预效果。
