早期肾脏特化、发育及模式形成的进展
Advances in early kidney specification, development and patterning.
作者信息
Dressler Gregory R
机构信息
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Development. 2009 Dec;136(23):3863-74. doi: 10.1242/dev.034876.
Abstract
The kidney is a model developmental system for understanding mesodermal patterning and organogenesis, a process that requires regional specification along multiple body axes, the proliferation and differentiation of progenitor cells, and integration with other tissues. Recent progress in the field has highlighted the essential roles of intrinsic nuclear factors and secreted signaling molecules in specifying renal epithelial stem cells and their self-renewal, in driving the complex dynamics of epithelial cell branching morphogenesis, and in nephron patterning. How these developments influence and advance our understanding of kidney development is discussed.
摘要
肾脏是用于理解中胚层模式形成和器官发生的一个典型发育系统，这一过程需要沿多个身体轴进行区域特化、祖细胞的增殖和分化以及与其他组织的整合。该领域的最新进展突出了内在核因子和分泌信号分子在确定肾上皮干细胞及其自我更新、驱动上皮细胞分支形态发生的复杂动态以及肾单位模式形成方面的重要作用。本文将讨论这些进展如何影响并推进我们对肾脏发育的理解。
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本文引用的文献
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Paraxial mesoderm contributes stromal cells to the developing kidney.轴旁中胚层为发育中的肾脏提供基质细胞。
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Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney.Osr1的表达界定了中肾间充质的一个多能细胞群体，该群体在哺乳动物肾脏内逐渐局限于一个依赖Osr1的肾单位祖细胞区室。
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