Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, China.
Cerebrovasc Dis. 2010;29(1):68-72. doi: 10.1159/000256649. Epub 2009 Nov 10.
Serine protease inhibitor member 3 of clade A (SERPINA3) has been shown as a risk factor for aneurysmal subarachnoid hemorrhage in a Polish population. In the present study, the authors investigated the correlation between the rs4934 polymorphism of SERPINA3 and sporadic intracranial aneurysms in Chinese patients.
The rs4934 polymorphism of SERPINA3 was identified by PCR and Taqman MGB probe analysis in genomic DNA from 275 patients with sporadic intracranial aneurysms (mean age 50.83 +/- 10.78 years) and 361 control participants (mean age 53.21 +/- 10.81 years). Differences in allelic and genotypic frequencies between the patient and control groups were evaluated with the chi(2) test.
No significant difference was found in either the genotype distribution or allelic frequencies of SERPINA3 between patients and controls.
The rs4934 polymorphism of SERPINA3 is not associated with sporadic intracranial aneurysms among individuals of Chinese Han ethnicity.
A 族丝氨酸蛋白酶抑制剂成员 3（SERPINA3）已被证明是波兰人群蛛网膜下腔出血动脉瘤的危险因素。在本研究中，作者研究了 SERPINA3 的 rs4934 多态性与中国患者散发性颅内动脉瘤之间的相关性。
采用 PCR 和 Taqman MGB 探针分析方法，在 275 例散发性颅内动脉瘤患者（平均年龄 50.83±10.78 岁）和 361 名对照参与者（平均年龄 53.21±10.81 岁）的基因组 DNA 中鉴定 SERPINA3 的 rs4934 多态性。采用卡方检验评估患者组和对照组之间等位基因和基因型频率的差异。
患者组和对照组之间 SERPINA3 的基因型分布或等位基因频率均无显著差异。
SERPINA3 的 rs4934 多态性与中国汉族人群的散发性颅内动脉瘤无关。
