Then P, Sandbichler P, Erhart R, Dietze O, Klima G, Vogel W, Margreiter R
Department of Transplant Surgery, University Hospital, Innsbruck, Austria.
Transplant Proc. 1991 Feb;23(1 Pt 1):892-3.
The lung was investigated as a matrix for transplanted hepatocytes in the rat model. Surgically induced fulminant hepatic failure was successfully treated by injection of 5 to 7 x 10(7) isolated hepatocytes into the pulmonary parenchyma in 86% of the animals. No animal, however, survived injection of hepatocytes into the jugular vein. It was found that liver failure is a prerequisite for the intrapulmonary survival of hepatocytes. After regeneration of the native liver, the majority of hepatocytes are cleared away within 6 months.
在大鼠模型中，研究了肺作为移植肝细胞的基质。通过将5至7×10⁷个分离的肝细胞注射到肺实质中，86%的动物成功治疗了手术诱导的暴发性肝衰竭。然而，没有一只动物在将肝细胞注射到颈静脉后存活。发现肝衰竭是肝细胞在肺内存活的先决条件。在天然肝脏再生后，大多数肝细胞在6个月内被清除。
