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内镜下第三脑室造瘘术:黎巴嫩的经验。

Endoscopic third ventriculostomy: the Lebanese experience.

作者信息

Rahme Ralph, Rahme Rudy J, Hourani Roula, Moussa Ronald, Nohra Georges, Okais Nabil, Samaha Elie, Rizk Tony

机构信息

Department of Neurosurgery, Saint-Joseph University and Hôtel-Dieu de France, Beirut, Lebanon.

出版信息

Pediatr Neurosurg. 2009;45(5):361-7. doi: 10.1159/000257525. Epub 2009 Nov 11.

Abstract

BACKGROUND

Endoscopic third ventriculostomy (ETV) has gained wide popularity as a first-line treatment for obstructive hydrocephalus (OHC). We have been performing ETV since 1998. We report our experience with this technique in the management of OHC.

METHODS

Between 1998 and 2007, we performed 49 ETV procedures in 46 patients suffering from OHC. Medical records were retrospectively reviewed. Success was defined as shunt-free survival.

RESULTS

There were 29 males and 17 females with a mean age of 23 years (6 months-65 years). Aqueductal stenosis and tectal tumor were the most common etiologies (63%). Seven patients (15.6%) had early ETV failure. Of 38 patients with initial success and available follow-up, shunt independence was achieved in 29 patients (76.3%) after a mean follow-up of 37 months. Kaplan-Meier analysis yielded a 70% 5-year shunt-free survival rate. On multivariate analysis, no variables could predict early or late ETV failure. Transient complications occurred in 6 patients (13%), but there were no ETV-related deaths or permanent morbidity.

CONCLUSION

ETV is a safe and effective treatment for OHC, resulting in a high rate of long-term shunt independence with a low risk of complications. ETV should be considered the treatment of choice for patients with OHC and its development as a substitute to shunt placement should be encouraged in neurosurgically developing countries.

摘要

背景

内镜下第三脑室造瘘术(ETV)作为梗阻性脑积水(OHC)的一线治疗方法已广泛普及。自1998年以来我们一直在开展ETV。我们报告我们应用该技术治疗OHC的经验。

方法

1998年至2007年间,我们对46例患有OHC的患者实施了49例ETV手术。对病历进行回顾性分析。成功定义为无需分流管存活。

结果

男性29例,女性17例,平均年龄23岁(6个月至65岁)。导水管狭窄和顶盖肿瘤是最常见的病因(63%)。7例患者(15.6%)早期ETV失败。在38例初始成功且有随访资料的患者中,平均随访37个月后,29例患者(76.3%)实现了无需分流管。Kaplan-Meier分析得出5年无需分流管生存率为70%。多因素分析显示,没有变量能够预测ETV早期或晚期失败。6例患者(13%)出现短暂并发症,但没有与ETV相关的死亡或永久性致残情况。

结论

ETV是治疗OHC的一种安全有效的方法,长期无需分流管的比例高,并发症风险低。对于OHC患者,ETV应被视为首选治疗方法,在神经外科发展中国家应鼓励其发展以替代分流管置入术。

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