粒细胞集落刺激因子在儿茶酚胺储备耗竭条件下对细胞生长抑制所致粒细胞生成抑制的影响。

Effect of granulocytic colony-stimulating factor on cytostatic-suppressed granulocytopoiesis under conditions of exhausted catecholamine depot.

作者信息

Dygai A M, Skurikhin E G, Pershina O V, Simanina E V, Minakova M Yu, Ermakova N N, Firsova T V, Khmelevskay E S

机构信息

Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.

出版信息

Bull Exp Biol Med. 2009 May;147(5):609-12. doi: 10.1007/s10517-009-0568-1.

DOI:10.1007/s10517-009-0568-1

PMID:19907751

Abstract

Exhaustion of catecholamine depot in the CNS before modeling of cytostatic myelosuppression potentiates the stimulatory effect of granulocytic CSF on regeneration of the granulocytic hemopoiesis stem. The increase in granulocyte count in the blood system under these conditions is caused by recovery of the structural and functional organization of the hemopoietic tissue (at the expense of reduction of the suppressive effect of catecholamines on the formation of granulocytic hemopoietic islets) and simultaneous stimulation of division and maturation of granulomonocytic precursors.

摘要

在进行细胞毒性骨髓抑制建模之前，中枢神经系统中儿茶酚胺储备的耗尽增强了粒细胞集落刺激因子对粒细胞造血干细胞再生的刺激作用。在这些条件下，血液系统中粒细胞计数的增加是由于造血组织的结构和功能组织恢复（这是以儿茶酚胺对粒细胞造血岛形成的抑制作用降低为代价）以及粒细胞单核细胞前体的分裂和成熟同时受到刺激所致。