Kalenova L F, Fisher T A, Suhovey J G, Besedin I M
Institute of Common and Applied Cryology, Tyumen State Oil and Gas University, Tyumen, Russia.
Bull Exp Biol Med. 2009 May;147(5):617-20. doi: 10.1007/s10517-009-0566-3.
Experiments on inbred animals showed that short-term exposure in cold water significantly modified structural and functional parameters of the immune system at different levels of its organization, from bone marrow hemopoiesis to effector stage of the immune response to antigen. The thermal factor caused changes in nonspecific and specific mechanisms of the immune system. Hypothermal exposure (7-9 degrees C, 5 sec) increased the thymic index and bone marrow lymphocyte count, reduced absorption capacity and stimulated metabolic activity of phagocytes, stimulated cell-mediated and suppressed humoral immunity. Contrast exposure in cold and hot water (7-9 degrees C, 5 sec/40-42 degrees C, 30 sec) increased monocyte count in bone marrow and reduced it in the their peripheral blood, reduced metabolic activity of phagocytes, stimulated cell-mediated and suppressed humoral immunity. These data demonstrate physiological mechanisms of interactions between the thermoregulatory and immune systems.
对近交系动物进行的实验表明，短期暴露于冷水中会显著改变免疫系统在其不同组织水平（从骨髓造血到对抗抗原的免疫反应效应阶段）的结构和功能参数。热因素会引起免疫系统非特异性和特异性机制的变化。低温暴露（7 - 9摄氏度，5秒）会增加胸腺指数和骨髓淋巴细胞计数，降低吞噬细胞的吸收能力并刺激其代谢活性，刺激细胞介导免疫并抑制体液免疫。冷热交替暴露（7 - 9摄氏度，5秒/40 - 42摄氏度，30秒）会增加骨髓中的单核细胞计数并减少外周血中的单核细胞计数，降低吞噬细胞的代谢活性，刺激细胞介导免疫并抑制体液免疫。这些数据证明了体温调节系统和免疫系统之间相互作用的生理机制。
