Department of Traditional Chinese Medicine,The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
Evid Based Complement Alternat Med. 2014;2014:373608. doi: 10.1155/2014/373608. Epub 2014 May 15.
Environmental dampness is one factor which can cause human diseases. The effects of exposure to humidity on human immune function are diverse and numerous. In the theory of traditional Chinese medicine (TCM), dampness is defined as one of the major pathogenic factors in the human body. It is divided into "external dampness" and "internal dampness." However the molecular mechanism leading to humidity-induced immunosuppression is obscure. In the present study, we investigated the expression of the T-cell antigen receptor variable β (TCRVβ) subfamilies in rats which were fed in different humid environment. And the expression levels of the TCRVβ subfamilies were detected using FQ-PCR. We found that the dampness might reduce the immunological recognition function of rats. And the obstruction of the immunological recognition function might be caused by internal dampness rather than external dampness.
环境潮湿是导致人类疾病的因素之一。暴露于湿度对人类免疫功能的影响是多种多样的。在中医（TCM）理论中，湿气被定义为人体主要致病因素之一。它分为“外湿”和“内湿”。然而，导致湿度引起的免疫抑制的分子机制尚不清楚。在本研究中，我们调查了在不同潮湿环境中饲养的大鼠 T 细胞抗原受体可变β（TCRVβ）亚家族的表达。并使用 FQ-PCR 检测 TCRVβ 亚家族的表达水平。我们发现，潮湿可能会降低大鼠的免疫识别功能。而免疫识别功能的障碍可能是由内湿引起的，而不是外湿。
