Department of Medicine, Alexandra Hospital, 378 Alexandra Road, Singapore.
Singapore Med J. 2009 Oct;50(10):997-1003.
The aim of this study was to analyse the association between the ACE ID polymorphism and aerobic capacity in a homogeneous cohort of national Asian rugby players.
17 subjects recruited during active training had their maximal oxygen uptake (V0 2 max) and ventilatory threshold (VT) measured during maximal exercise testing. ACE genotyping was performed for all players.
The likelihood of having a V0 2 max above the 80th percentile of a gender-specific reference range for a normal population was 14.3-fold greater among subjects with the II genotype as compared to the ID genotype (p-value is 0.030). Similarly, subjects with the II genotype were 29.4 times more likely to have a VT above the gender-specific median value compared to the ID genotype (p-value is 0.019). The results suggest that the I allele confers an advantage in aerobic capacity as measured by the V0 2 max and VT.
It is likely that the same physiological mechanisms mediated by the ACE gene are responsible for aerobic capacity in both Asians and Caucasians.
本研究旨在分析 ACE ID 多态性与亚洲国家橄榄球运动员有氧能力的关系。
在主动训练期间招募了 17 名受试者，在最大运动测试期间测量了他们的最大摄氧量（V0 2 max）和通气阈值（VT）。对所有运动员进行 ACE 基因分型。
与 ID 基因型相比，II 基因型受试者的 V0 2 max 超过正常人群性别特异性参考范围第 80 百分位数的可能性高 14.3 倍（p 值为 0.030）。同样，与 ID 基因型相比，II 基因型受试者的 VT 超过性别特异性中位数的可能性高 29.4 倍（p 值为 0.019）。结果表明，I 等位基因在通过 V0 2 max 和 VT 测量的有氧能力方面具有优势。
ACE 基因介导的相同生理机制可能负责亚洲人和高加索人有氧能力。
