Department of Nephrology, Gulhane School of Medicine, Ankara, Turkey.
Rheumatol Int. 2011 Aug;31(8):1085-7. doi: 10.1007/s00296-009-1227-6. Epub 2009 Oct 27.
Diffuse alveolar hemorrhage (DAH) is rarely seen in patients with systemic lupus erythematosus (SLE), often associated with a poor outcome. It almost affects young women and it is an unusual initial manifestation of SLE. We report a case of SLE presenting with DAH. The patient was a male. He had no history of photosensitivity, malar rash, discoid rash, arthritis, and oral ulcer. Antinuclear antibody, and anti-double stranded DNA (dsDNA) were positive with very high titers, and serum complement levels (C3, C4) were low. He also had renal dysfunction and pericardial effusion. He was diagnosed as DAH due to SLE. He had to undergo hemodialysis for several weeks. DAH and renal dysfunction were improved with intensive treatment including corticosteroid, cyclophosphamide, and mycophenolate mophetil.
弥漫性肺泡出血（DAH）在系统性红斑狼疮（SLE）患者中很少见，常与预后不良有关。它几乎影响年轻女性，是 SLE 的一种不常见的初始表现。我们报告一例以 DAH 为表现的 SLE 病例。患者为男性，无光过敏、蝶形红斑、盘状红斑、关节炎和口腔溃疡病史。抗核抗体和抗双链 DNA（dsDNA）阳性，滴度很高，血清补体水平（C3、C4）降低。他还患有肾功能不全和心包积液。他被诊断为因 SLE 引起的 DAH。他不得不接受数周的血液透析。经过皮质类固醇、环磷酰胺和霉酚酸酯等强化治疗，DAH 和肾功能不全得到改善。
