探索婴幼儿自闭症样特质与 ADHD 行为之间的关系：来自一项针对 2 岁儿童的社区双胞胎研究的发现。
Exploring the relationship between autistic-like traits and ADHD behaviors in early childhood: findings from a community twin study of 2-year-olds.
机构信息
Centre for Brain and Cognitive Development, School of Psychology, Birkbeck College, Malet Street, London WC1E 7HX, UK.
出版信息
J Abnorm Child Psychol. 2010 Feb;38(2):185-96. doi: 10.1007/s10802-009-9366-5.
Abstract
Behaviors characteristic of autism and ADHD emerge in early childhood, yet research investigating their comorbidity has focused on older children. This study aimed to explore the nature of the relationship between autistic-like traits and ADHD behaviors in a community sample of 2-year-olds. Twins from the Boston University Twin Project (N = 312 pairs) were assessed by their parents on autistic-like traits and ADHD behaviors using the Childhood Behavior Checklist. Phenotypic analyses showed that after controlling for general cognitive ability and socioeconomic status, autistic-like traits (total scale as well as social and nonsocial subscales) correlated positively with ADHD behaviors (r = 0.23-0.26). Structural equation model-fitting analyses revealed that there were modest shared genetic influences between ADHD- and autistic traits (genetic correlation = 0.27) as well as some common environmental influences explaining their covariation. Implications for identifying shared biological pathways underlying autistic-like traits and ADHD behaviors are discussed.
摘要
自闭症和 ADHD 的行为特征出现在幼儿期，但研究自闭症和 ADHD 的共病现象的研究重点是年龄较大的儿童。本研究旨在探索自闭症样特征与 ADHD 行为之间的关系，研究对象为社区样本中的 2 岁儿童。来自波士顿大学双胞胎项目的双胞胎（N = 312 对）的父母使用儿童行为检查表评估他们的自闭症样特征和 ADHD 行为。表型分析表明，在控制一般认知能力和社会经济地位后，自闭症样特征（总分以及社会和非社会分量表）与 ADHD 行为呈正相关（r = 0.23-0.26）。结构方程模型拟合分析表明，ADHD 特征和自闭症样特征之间存在适度的共同遗传影响（遗传相关=0.27），以及一些共同的环境影响解释了它们的共同变化。讨论了识别自闭症样特征和 ADHD 行为的共同生物学途径的意义。
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