Zender H O, Olivier P, Genné D
Service des soins intensifs, Département de médecine cantonal, Hôpital neuchâtelois-La Chaux-de-Fonds, Rue de Chasseral 20, 2300 La Chaux-de-Fonds.
Rev Med Suisse. 2009 Oct 7;5(220):1968-70, 1972-4.
Bacterial meningitis in adults is fatal in 20% of patients and leads to sequels in 30%. The clinical presentation includes two of the following four symptoms and signs: fever, headache, stiff neck, altered mental status. The essential ancillary test is the analysis of the cerebrospinal fluid. Sometimes, the lumbar puncture is not feasible or deferred (brain computer tomography), requiring antibiotics and corticosteroids early. 80% of bacterial meningitis are secondary to pneumococcus or meningococcus. Empirical antibiotics must be given as soon as possible and provide coverage for these both bacteria. Corticosteroids are also recommended for some meningitis. A score can predict the evolution. Preventive measure must be taken for close contacts of a patient with a meningococcal meningitis.
成人细菌性脑膜炎患者的死亡率为20%,30%会留有后遗症。临床表现包括以下四种症状和体征中的两种:发热、头痛、颈部僵硬、精神状态改变。重要的辅助检查是脑脊液分析。有时,腰椎穿刺不可行或需推迟(进行脑部计算机断层扫描),这就需要尽早使用抗生素和皮质类固醇。80%的细菌性脑膜炎继发于肺炎球菌或脑膜炎球菌。必须尽快给予经验性抗生素治疗,且要覆盖这两种细菌。对于某些脑膜炎也推荐使用皮质类固醇。有一种评分方法可以预测病情发展。对于患脑膜炎球菌性脑膜炎患者的密切接触者,必须采取预防措施。