de Meis Ernesto, Pinheiro Vera R, Zamboni Mauro M, Guedes Maria Teresa S, Castilho Ilda A M, Martinez Maria Mercedes K, Leda Marys Stella O, Silveira Neura P R, Rumjanek Vivian M, Levy Roger A
Clinical Pathology, Instituto Nacional do Câncer, Praça Cruz Vermelha 23, Centro, Rio de Janeiro, 20230-130, Brazil.
Cancer Invest. 2009 Dec;27(10):989-97. doi: 10.3109/07357900903124464.
Thrombosis is highly prevalent in cancer patients, being accepted as a bad prognosis marker. The importance of various mechanisms involved in the thrombophilic state of lung cancer patients is not well understood. In this prospective study, involving 109 unselected patients with lung adenocarcinoma, thrombosis was present in 24% of patients and affected survival in a bivariable model. However, in a multivariable evaluation, considering all the factors under study, only LAC and IgM anti-beta(2) GP I modified thrombosis risk, whereas in a Kaplan-Meyer regression model, thrombosis, IL-6, LAC, factor VIII, and IgM anti-beta(2) GP I interfered with patient's survival.
血栓形成在癌症患者中非常普遍，被认为是预后不良的标志物。肺癌患者血栓形成倾向状态中涉及的各种机制的重要性尚未得到充分理解。在这项前瞻性研究中，纳入了109例未经选择的肺腺癌患者，24%的患者存在血栓形成，并且在双变量模型中影响生存。然而，在多变量评估中，考虑所有研究因素，只有狼疮抗凝物（LAC）和IgM抗β2糖蛋白I改变了血栓形成风险，而在Kaplan-Meier回归模型中，血栓形成、白细胞介素-6（IL-6）、LAC、凝血因子VIII和IgM抗β2糖蛋白I干扰了患者的生存。
