Department of Medicine, AI Virtanen Institute, University of Kuopio, Kuopio, Finland.
Biochem Soc Trans. 2009 Dec;37(Pt 6):1198-200. doi: 10.1042/BST0371198.
Therapeutic angiogenesis is a promising new concept for the treatment of myocardial and peripheral ischaemia. Members of the VEGF (vascular endothelial growth factor) family are among the most powerful modulators of angiogenesis. They regulate vascular growth and maintenance during embryogenesis and in adults. The present review summarizes the current status of therapeutic angiogenesis using VEGF, with special reference to preclinical studies.
治疗性血管生成是治疗心肌和外周缺血的一种很有前途的新概念。VEGF（血管内皮生长因子）家族的成员是血管生成的最强调节剂之一。它们在胚胎发生和成人期调节血管的生长和维持。本文综述了使用 VEGF 的治疗性血管生成的现状，特别参考了临床前研究。
