Experimental Cardiovascular Medicine, Bristol Heart Institute, University of Bristol, Bristol, UK.
Biochem Soc Trans. 2009 Dec;37(Pt 6):1221-7. doi: 10.1042/BST0371221.
Notch signalling represents a key pathway essential for normal vascular development. Recently, great attention has been focused on the implication of Notch pathway components in postnatal angiogenesis and regenerative medicine. This paper critically reviews the most recent findings supporting the role of Notch in ischaemia-induced neovascularization. Notch signalling reportedly regulates several steps of the reparative process occurring in ischaemic tissues, including sprouting angiogenesis, vessel maturation, interaction of vascular cells with recruited leucocytes and skeletal myocyte regeneration. Further characterization of Notch interaction with other signalling pathways might help identify novel targets for therapeutic angiogenesis.
Notch 信号通路是正常血管发育所必需的关键途径。最近，人们越来越关注 Notch 通路成分在血管生成和再生医学中的作用。本文批判性地回顾了支持 Notch 在缺血诱导的新生血管形成中的作用的最新发现。据报道，Notch 信号通路调节缺血组织中发生的修复过程的几个步骤，包括发芽血管生成、血管成熟、血管细胞与募集的白细胞的相互作用以及骨骼肌细胞的再生。进一步研究 Notch 与其他信号通路的相互作用可能有助于确定治疗性血管生成的新靶点。
