National Heart and Lung Institute (NHLI) Cardiovascular Sciences Unit, Hammersmith Hospital, Imperial College London, London W12 0NN, UK.
Biochem Soc Trans. 2009 Dec;37(Pt 6):1248-53. doi: 10.1042/BST0371248.
Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally, we discuss novel evidence that shows how these transcription factors act in a combinatorial fashion with others, through composite sites that may be crucial in determining endothelial specificity in gene transcription.
ETS 家族的转录因子是内皮细胞基因表达的重要调节因子。在这里，我们回顾了 ETS 因子调节血管生成的证据，并简要讨论了涉及的靶基因和途径。最后，我们讨论了新的证据，表明这些转录因子如何通过可能在决定基因转录中内皮细胞特异性方面起关键作用的组合位点与其他转录因子以组合方式发挥作用。
