Department of Physiology, Anatomy and Genetics, Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK.
Dev Dyn. 2024 Jan;253(1):28-58. doi: 10.1002/dvdy.575. Epub 2023 Mar 6.
Transcription factors (TFs) play a crucial role in regulating the dynamic and precise patterns of gene expression required for the initial specification of endothelial cells (ECs), and during endothelial growth and differentiation. While sharing many core features, ECs can be highly heterogeneous. Differential gene expression between ECs is essential to pattern the hierarchical vascular network into arteries, veins and capillaries, to drive angiogenic growth of new vessels, and to direct specialization in response to local signals. Unlike many other cell types, ECs have no single master regulator, instead relying on differing combinations of a necessarily limited repertoire of TFs to achieve tight spatial and temporal activation and repression of gene expression. Here, we will discuss the cohort of TFs known to be involved in directing gene expression during different stages of mammalian vasculogenesis and angiogenesis, with a primary focus on development.
转录因子 (TFs) 在调节内皮细胞 (ECs) 初始特化和内皮生长分化所需的基因表达的动态和精确模式方面发挥着关键作用。尽管具有许多核心特征，但 ECs 可以高度异质。ECs 之间的差异基因表达对于将层次化的血管网络模式化为动脉、静脉和毛细血管，驱动新血管的血管生成生长，以及根据局部信号指导特化是必不可少的。与许多其他细胞类型不同，ECs 没有单一的主调控因子，而是依赖于有限的转录因子组合的不同组合来实现基因表达的紧密时空激活和抑制。在这里，我们将讨论已知在哺乳动物血管发生和血管生成的不同阶段指导基因表达的 TF 群体，主要关注发育。
