NWCRF Institute, School of Biological Sciences, College of Natural Sciences, Bangor University, Bangor LL57 2UW, UK.
Biochem Soc Trans. 2009 Dec;37(Pt 6):1254-9. doi: 10.1042/BST0371254.
ERK5 (extracellular-signal-regulated kinase 5), also termed BMK1 [big MAPK1 (mitogen-activated protein kinase 1)], is the most recently discovered member of the MAPK family. It is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling, regulating hypoxia, tumour angiogenesis and cell migration. This review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.
ERK5（细胞外信号调节激酶 5），也称为 BMK1[大 MAPK1（丝裂原活化蛋白激酶 1）]，是 MAPK 家族中最新发现的成员。它在多种组织中表达，并被一系列生长因子、细胞因子和细胞应激激活。在小鼠中靶向性缺失 Erk5 已揭示 ERK5 信号级联对于正常心血管发育和血管完整性至关重要。体外研究表明，在内皮细胞中，ERK5 对于防止细胞凋亡、介导切应力信号、调节缺氧、肿瘤血管生成和细胞迁移是必需的。这篇综述重点介绍了我们目前对 ERK5 调节内皮细胞功能的作用的理解。
