细胞外信号调节激酶5（ERK5）在内皮细胞功能中的作用。
The role of ERK5 in endothelial cell function.
作者信息
Nithianandarajah-Jones Gopika N, Wilm Bettina, Goldring Christopher E P, Müller Jürgen, Cross Michael J
机构信息
*MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, U.K.
†Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, U.K.
出版信息
Biochem Soc Trans. 2014 Dec;42(6):1584-9. doi: 10.1042/BST20140276.
Extracellular-signal-regulated kinase 5 (ERK5), also termed big MAPK1 (BMK1), is the most recently discovered member of the mitogen-activated protein kinase (MAPK) family. It is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that, in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.
细胞外信号调节激酶5（ERK5），也称为大丝裂原活化蛋白激酶1（BMK1），是丝裂原活化蛋白激酶（MAPK）家族中最新发现的成员。它在多种组织中表达，并被一系列生长因子、细胞因子和细胞应激激活。在小鼠中靶向缺失Erk5已表明，ERK5信号级联对于正常心血管发育和血管完整性至关重要。体外研究表明，在内皮细胞中，ERK5对于预防细胞凋亡、介导剪切应力信号传导和调节肿瘤血管生成是必需的。本综述重点关注我们目前对ERK5在调节内皮细胞功能中作用的理解。
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