α5 型 GABA A 受体的生理特性和治疗潜力。
The physiological properties and therapeutic potential of alpha5-GABAA receptors.
机构信息
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
出版信息
Biochem Soc Trans. 2009 Dec;37(Pt 6):1334-7. doi: 10.1042/BST0371334.
The notion that drug treatments can improve memory performance has moved from the realm of science fiction to that of serious investigation. A popular working hypothesis is that cognition can be improved by altering the balance between excitatory and inhibitory neurotransmission. This review focuses on the unique physiological and pharmacological properties of GABA(A)Rs [GABA (gamma-aminobutyric acid) subtype A receptors] that contain the alpha(5) subunit (alpha(5)-GABA(A)R), as these receptors serve as candidate targets for memory-enhancing drugs.
药物治疗可以改善记忆表现的观点已经从科幻小说领域进入到严肃的研究领域。一个流行的工作假设是，通过改变兴奋性和抑制性神经递质传递之间的平衡，可以改善认知。这篇综述的重点是含有 alpha(5)亚基（alpha(5)-GABA(A)R）的 GABA(A)R [GABA (gamma-aminobutyric acid) 亚型 A 受体]的独特生理和药理学特性，因为这些受体是增强记忆药物的候选靶标。
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