Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.
Biochem Soc Trans. 2009 Dec;37(Pt 6):1385-8. doi: 10.1042/BST0371385.
Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures.
慢性暴露于谷氨酸（谷氨酸兴奋性毒性）会加剧中风后的神经元损伤，并与多种神经退行性疾病有关。线粒体在暴露神经元的存活或死亡中起着核心作用。钙、氧化应激和 ATP 不足起着紧密相关的作用，可以通过原代神经元培养来研究这些作用。
