Lymphocyte Development Laboratory, Clinical Research Institute of Montreal, Montreal, QC, Canada.
Immunol Rev. 2009 Nov;232(1):22-33. doi: 10.1111/j.1600-065X.2009.00835.x.
Assembly, expression, and signal transduction by the pre-T-cell receptor (pre-TCR) and TCR complexes are critical for normal thymocyte development. How environmental cues sensed by these two receptor complexes are translated into biological responses that result in the generation of functionally mature T cells is increasingly better understood. Invariant CD3gamma, delta, epsilon, and zeta polypeptides are central to the function of these two receptor complexes. CD3 chains ensure correct intracellular assembly, surface expression, and signal transduction via the receptors in ligand-independent and -dependent manners. In the present review, the roles of the CD3 chains, particularly CD3gamma, delta, and epsilon, in thymocyte differentiation in mice and humans are reviewed.
组装、表达和前 T 细胞受体 (pre-TCR) 和 TCR 复合物的信号转导对于正常胸腺细胞的发育至关重要。这两种受体复合物感知的环境线索如何转化为生物反应，从而产生功能成熟的 T 细胞，人们对此的理解越来越深入。不变的 CD3γ、δ、ε 和 ζ 多肽是这两种受体复合物功能的核心。CD3 链通过受体以配体非依赖和依赖的方式确保正确的细胞内组装、表面表达和信号转导。在本综述中，我们回顾了 CD3 链，特别是 CD3γ、δ 和 ε，在小鼠和人类胸腺细胞分化中的作用。
