Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.
Gynecol Oncol. 2010 Mar;116(3):430-7. doi: 10.1016/j.ygyno.2009.10.056. Epub 2009 Nov 11.
The behaviors of placental site trophoblastic tumor (PSTT), especially lymphatic spread, have not been completely understood. We aimed to investigate the nature of lymphatic spread in PSTT as well as the expression of several molecules on tumor.
The clinical data of 5 cases with PSTT were reviewed retrospectively. The expression of EGFR, VEGF, HER2/neu, and CD117 was analyzed by immunohistochemical staining. A MEDLINE search was performed to identify patients with PSTT.
There were several special aspects in our 5 cases. One patient was postmenopausal and had a 33-year long interval from antecedent pregnancy; two patients had lymph node and ovarian involvement each; the postmenopausal patient had 4 relapses and survived 57 months after the first recurrence. Tumor cells in all cases were strongly positive for EGFR and VEGF and negative for HER2/neu and CD117. A total of 286 cases (281 from the literature and 5 from our data) were analyzed for lymphatic spread. Of them, 17 (5.9%) had lymph node metastases, including pelvic in 5 patients, para-aortic in 7, retroperitoneal but not specified in 2, and other sites in 6.
Lymph node metastasis is one way of spread in PSTT. Retroperitoneal node, especially para-aortic node, is the most common site of lymphatic spread. EGFR and VEGF may be commonly expressed in PSTT tumors.
胎盘部位滋养细胞肿瘤（PSTT）的行为，特别是淋巴转移，尚未完全了解。我们旨在研究 PSTT 中淋巴转移的性质以及肿瘤上几种分子的表达。
回顾性分析 5 例 PSTT 患者的临床资料。采用免疫组织化学染色分析 EGFR、VEGF、HER2/neu 和 CD117 的表达。通过 MEDLINE 搜索确定患有 PSTT 的患者。
我们的 5 例患者有几个特殊方面。1 例为绝经后患者，距前次妊娠有 33 年的间隔；2 例各有淋巴结和卵巢受累；绝经后患者有 4 次复发，在首次复发后存活 57 个月。所有病例的肿瘤细胞均对 EGFR 和 VEGF 呈强阳性，对 HER2/neu 和 CD117 呈阴性。共分析了 286 例（281 例来自文献，5 例来自我们的数据）发生淋巴转移的病例。其中，17 例（5.9%）有淋巴结转移，包括 5 例盆腔、7 例主动脉旁、2 例腹膜后但未特指、6 例其他部位。
淋巴结转移是 PSTT 的一种转移方式。腹膜后淋巴结，尤其是主动脉旁淋巴结，是最常见的淋巴转移部位。EGFR 和 VEGF 可能在 PSTT 肿瘤中普遍表达。
