Centre for Health, Exercise and Sports Medicine, School of Physiotherapy, University of Melbourne, Victoria, Australia.
Ann Rheum Dis. 2010 Jun;69(6):1151-4. doi: 10.1136/ard.2009.118182. Epub 2009 Nov 11.
To evaluate the relationship between mechanical loading, as indicated by the external knee adduction moment (KAM) during walking, and BML on MRI in people with medial knee osteoarthritis.
Measures were taken in 91 individuals with medial knee osteoarthritis. Logistic regression analyses were performed with the presence/absence of medial tibial or medial femoral BML as the outcome and either peak KAM or KAM impulse as the independent variable. Analyses were also adjusted for age, gender, body mass index, alignment and walking speed.
In adjusted analyses, peak KAM was significantly related to medial tibial (OR 2.3; 95%CI 1.07 to 4.7), but not medial femoral (OR 1.85; 95%CI 0.93 to 3.7) BML. KAM impulse was significantly related to both medial tibial (OR 9.4; 95%CI 1.53 to 57.2) and medial femoral (OR 14.4; 95%CI 2.3 to 89.8) BML.
The findings support the hypothesis that greater mechanical loading of the medial compartment plays a role in the pathogenesis of BML in medial tibiofemoral osteoarthritis.
评估膝关节内收力矩（KAM）在行走过程中所代表的机械负荷与内侧膝关节骨关节炎患者 MRI 上 BML 之间的关系。
共纳入 91 名内侧膝关节骨关节炎患者。以存在/不存在内侧胫骨或内侧股骨 BML 为结局，以峰值 KAM 或 KAM 冲量为自变量，进行逻辑回归分析。分析还调整了年龄、性别、体重指数、对线和步行速度。
在调整后的分析中，峰值 KAM 与内侧胫骨（OR 2.3；95%CI 1.07 至 4.7）但与内侧股骨（OR 1.85；95%CI 0.93 至 3.7）BML 显著相关。KAM 冲量与内侧胫骨（OR 9.4；95%CI 1.53 至 57.2）和内侧股骨（OR 14.4；95%CI 2.3 至 89.8）BML 均显著相关。
这些发现支持了这样一种假说，即内侧间室更大的机械负荷在内侧胫股性骨关节炎的 BML 发病机制中起作用。
