参考组织模型与血脑屏障破坏：创伤性脑损伤中(R)-[11C]PK11195的经验教训
Reference tissue models and blood-brain barrier disruption: lessons from (R)-[11C]PK11195 in traumatic brain injury.
作者信息
Folkersma Hedy, Boellaard Ronald, Vandertop W Peter, Kloet Reina W, Lubberink Mark, Lammertsma Adriaan A, van Berckel Bart N M
机构信息
Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
出版信息
J Nucl Med. 2009 Dec;50(12):1975-9. doi: 10.2967/jnumed.109.067512. Epub 2009 Nov 12.
UNLABELLED
(R)-[(11)C]PK11195 is a tracer for activated microglia. The purpose of this study was to assess the validity of the simplified reference tissue model for analyzing (R)-[(11)C]PK11195 studies in traumatic brain injury (TBI), where blood-brain barrier disruptions are likely.
METHODS
Dynamic (R)-[(11)C]PK11195 scans were acquired at 3 time points after TBI. Plasma input-derived binding potential (BP(ND)(PI)), volume of distribution (V(T)) and K(1)/k(2), and simplified reference tissue model-derived binding potential (BP(ND)(SRTM)) were obtained. Simulations were performed to assess the effect of varying K(1)/k(2).
RESULTS
Early after TBI, an increase in V(T), but not in BP(ND)(PI), was found. Early K(1)/k(2) correlated with V(T) and BP(ND)(SRTM) but not with BP(ND)(PI). One and 6 mo after TBI, BP(ND)(SRTM) correlated with BP(ND)(PI).
CONCLUSION
Early after TBI, (R)-[(11)C]PK11195 studies should be analyzed using plasma input models.
未标注
（R）-[（11）C]PK11195是一种用于活化小胶质细胞的示踪剂。本研究的目的是评估简化参考组织模型在分析创伤性脑损伤（TBI）中（R）-[（11）C]PK11195研究的有效性，在TBI中血脑屏障可能会被破坏。
方法
在TBI后的3个时间点进行动态（R）-[（11）C]PK11195扫描。获得血浆输入衍生的结合潜能（BP（ND）（PI））、分布容积（V（T））和K（1）/k（2），以及简化参考组织模型衍生的结合潜能（BP（ND）（SRTM））。进行模拟以评估改变K（1）/k（2）的影响。
结果
在TBI后早期，发现V（T）增加，但BP（ND）（PI）未增加。早期的K（1）/k（2）与V（T）和BP（ND）（SRTM）相关，但与BP（ND）（PI）无关。在TBI后1个月和6个月，BP（ND）（SRTM）与BP（ND）（PI）相关。
结论
在TBI后早期，（R）-[（11）C]PK11195研究应使用血浆输入模型进行分析。
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