Specks U, Colby T V, Olsen K D, DeRemee R A
Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn. 55905.
Arch Otolaryngol Head Neck Surg. 1991 Feb;117(2):218-23. doi: 10.1001/archotol.1991.01870140106018.
Salivary gland involvement is a rare clinical feature of Wegener's granulomatosis. We report a series of five cases in which submandibular or parotid gland swelling was part of the initial manifestation of the disease. All patients had limited forms of Wegener's granulomatosis. The value of determination of serum anti-neutrophil cytoplasmic autoantibodies is demonstrated in four of the cases, and its use as a new diagnostic adjunct and promising tool to monitor disease activity is discussed. The use of trimethoprim-sulfamethoxazole as part of alternative treatment regimens for limited Wegener's granulomatosis is advocated.
唾液腺受累是韦格纳肉芽肿病罕见的临床特征。我们报告了一系列5例病例，其中下颌下腺或腮腺肿大是该疾病初始表现的一部分。所有患者均为局限性韦格纳肉芽肿病。4例病例显示了测定血清抗中性粒细胞胞浆自身抗体的价值，并讨论了其作为一种新的诊断辅助手段和监测疾病活动的有前景工具的应用。提倡将甲氧苄啶-磺胺甲恶唑用作局限性韦格纳肉芽肿病替代治疗方案的一部分。
