Department of Gynecology, Catholic University of Louvain, Brussels, Belgium.
Minerva Med. 2009 Oct;100(5):401-13.
Advances in the diagnosis and treatment of childhood, adolescent and adult cancer have greatly increased the life expectancy of premenopausal women with cancer. The ovaries are very sensitive to cytotoxic treatment, especially to alkylating agents. The only established method of fertility preservation is embryo cryopreservation according to the Ethics Committee of the American Society for Reproductive Medicine (2005), but this option requires the patient to be of pubertal age, have a partner or use donor sperm, and be able to undergo a cycle of ovarian stimulation, which is not possible when the chemotherapy has to be initiated immediately or when stimulation is contraindicated according to the type of cancer. For patients who need immediate chemotherapy, cryopreservation of ovarian tissue is the only possible alternative. This manuscript reports the techniques and results of orthotopic transplantation of cryopreserved ovarian tissue. Among almost 30 cases reported in the literature, seven live births have been achieved to date.
儿童、青少年和成人癌症的诊断和治疗的进步大大提高了患有癌症的绝经前妇女的预期寿命。卵巢对细胞毒性治疗非常敏感，尤其是烷化剂。根据美国生殖医学学会伦理委员会（2005 年）的规定，唯一确定的生育力保存方法是胚胎冷冻保存，但该选择要求患者处于青春期，有伴侣或使用供体精子，并且能够接受卵巢刺激周期，但当必须立即开始化疗或根据癌症类型不适合刺激时，这是不可能的。对于需要立即进行化疗的患者，冷冻卵巢组织的保存是唯一可行的选择。本文报告了冷冻卵巢组织的原位移植技术和结果。在文献中报告的近 30 例病例中，迄今为止已经实现了 7 例活产。
