University of Pennsylvania, 331 John Morgan Building/6112, 3620 Hamilton Walk, Philadelphia, PA 19104-4215, USA.
Expert Opin Investig Drugs. 2009 Dec;18(12):1919-27. doi: 10.1517/13543780903376163.
Polidocanol is a liquid surfactant having endothelial cell lytic properties. In the form of a controlled, dispensed microfoam it is administered endovenously as a sclerosing agent in the treatment of varicose veins.
This review summarizes efficacy of polidocanol endovenous microfoam sclerotherapy using a proprietary dispensing system to control foam characteristics and gas content for treating varicose veins.
We reviewed in vitro, Phase I, Phase II and limited Phase III data for polidocanol microfoam with a focus on controlled foam formulation in therapy.
RESULTS/CONCLUSIONS: Clinical trials of controlled dispensing of polidocanol microfoam provide evidence of effective treatment of chronic venous insufficiency with low toxicity, minimal risk and few complications.
聚多卡醇是一种具有血管内皮细胞溶血性的液体表面活性剂。以受控的、分散的微泡形式,作为静脉内硬化剂,用于治疗静脉曲张。
本综述总结了使用专有的分配系统控制泡沫特性和气体含量的聚多卡醇静脉内微泡硬化疗法治疗静脉曲张的疗效。
我们回顾了聚多卡醇微泡的体外、I 期、II 期和有限的 III 期数据,重点是治疗中的受控泡沫配方。
结果/结论:聚多卡醇微泡受控分配的临床试验提供了有效治疗慢性静脉功能不全的证据,具有低毒性、最小风险和很少并发症。