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痔病的硬化治疗:一项经典疗法的近期进展

Sclerotherapy for hemorrhoidal disease: Recent evolutions of an oldies goldy.

作者信息

Gravante Gianpiero

机构信息

Department of General Surgery, Azienda Sanitaria Locale (ASL) Lecce, Casarano 73042, Lecce, Italy.

出版信息

World J Gastroenterol. 2025 Feb 28;31(8):98704. doi: 10.3748/wjg.v31.i8.98704.

DOI:10.3748/wjg.v31.i8.98704
PMID:40062327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11886522/
Abstract

Treatments for low degree hemorrhoids (I-III degree) are numerous and so are their counterparts for higher degrees. These treatments present nebulous differences in terms of indications and outcomes among techniques. Methods previously abandoned due to side effects and long-term results have recently rejoined the mainstream due to recent peculiar modifications: Hemorrhoidal sclerotherapy is enjoying a new age of interest due to the use of the foam form of polidocanol, which is more effective than the liquid one. Various articles have already shown promising results and the logical next step is the combination of polidocanol foam with rubber-band ligation (the historical counterpart of sclerotherapy) in a technique called "sclerobanding". In this article, we comment on the publication by Qu further modifying the use of sclerobanding through an endoscopic delivery for patients with grade II-III internal hemorrhoids, and present results compared with endoscopic rubber band ligation. The results achieved are promising.

摘要

低度痔疮(I - III度)的治疗方法众多,高度痔疮的治疗方法同样如此。这些治疗方法在技术的适应症和疗效方面存在模糊的差异。由于副作用和长期效果而先前被摒弃的方法,近来因一些特殊的改进而重新回归主流:硬化剂注射疗法因使用聚多卡醇泡沫剂而迎来了新的关注时期,聚多卡醇泡沫剂比液体剂型更有效。各种文章已经显示出了有前景的结果,合乎逻辑的下一步是在一种名为“硬化套扎术”的技术中将聚多卡醇泡沫剂与橡皮圈套扎术(硬化剂注射疗法的传统对应方法)相结合。在本文中,我们对屈氏等人的出版物进行评论,该出版物通过内镜给药进一步改进了II - III度内痔患者的硬化套扎术的应用,并呈现了与内镜橡皮圈套扎术相比的结果。所取得的结果很有前景。

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引用本文的文献

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World J Gastrointest Surg. 2025 Jul 27;17(7):107099. doi: 10.4240/wjgs.v17.i7.107099.
2
Real-world use of polidocanol foam sclerotherapy for hemorrhoidal disease: insights from an international survey and systematic review with clinical practice recommendations.聚多卡醇泡沫硬化疗法在痔疮疾病中的实际应用:来自一项国际调查的见解以及带有临床实践建议的系统评价
Updates Surg. 2025 Jun 6. doi: 10.1007/s13304-025-02258-2.

本文引用的文献

1
Endoscopic polidocanol foam sclerobanding for the treatment of grade II-III internal hemorrhoids: A prospective, multi-center, randomized study.内镜下聚多卡醇泡沫硬化套扎术治疗Ⅱ-Ⅲ度内痔:一项前瞻性、多中心、随机研究。
World J Gastroenterol. 2024 Jul 21;30(27):3326-3335. doi: 10.3748/wjg.v30.i27.3326.
2
Sclerotherapy with 3% polidocanol foam for the treatment of mucocutaneous bridges and/or residual piles after open excisional hemorrhoidectomy.聚多卡醇泡沫硬化剂注射治疗痔切除术后黏膜桥和(或)残余痔赘
Updates Surg. 2024 Sep;76(5):2087-2090. doi: 10.1007/s13304-024-01798-3. Epub 2024 Mar 13.
3
Sclerobanding in the treatment of second and third degree hemorrhoidal disease in high risk patients on antiplatelet/anticoagulant therapy without suspension: a pilot study.在不中断抗血小板/抗凝治疗的高危患者中,硬化剂注射治疗二度和三度痔病的一项初步研究。
Front Surg. 2023 Nov 6;10:1290706. doi: 10.3389/fsurg.2023.1290706. eCollection 2023.
4
Results of sclerotherapy and mucopexy with haemorrhoidal dearterialization in II and III degree haemorrhoids. A 4 years' single centre experience.硬化疗法联合痔动脉结扎术及黏膜固定术治疗Ⅱ、Ⅲ度痔疮的效果:一项为期4年的单中心经验。
Front Surg. 2023 Jun 19;10:1151327. doi: 10.3389/fsurg.2023.1151327. eCollection 2023.
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HEmoRhoidal disease management with Band ligation versus polidocanol Sclerotherapy: a systematic review and meta-analysis (the HerBS Review).痔病管理中胶圈套扎与聚桂醇硬化治疗的比较:系统评价和荟萃分析(HerBS 评价)。
Int J Colorectal Dis. 2023 May 3;38(1):112. doi: 10.1007/s00384-023-04394-w.
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Sclerotherapy with 3% polidocanol foam to treat second-degree haemorrhoidal disease: Three-year follow-up of a multicentre, single arm, IDEAL phase 2b trial.聚多卡醇泡沫硬化疗法治疗 II 度痔病:多中心、单臂、IDEAL 2b 期临床试验三年随访。
Colorectal Dis. 2023 Mar;25(3):386-395. doi: 10.1111/codi.16380. Epub 2022 Nov 9.
7
Sclerotherapy for III- and IV-degree hemorrhoids: Results of a prospective study.III度和IV度痔疮的硬化治疗:一项前瞻性研究的结果
Front Surg. 2022 Sep 1;9:978574. doi: 10.3389/fsurg.2022.978574. eCollection 2022.
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