Scientific Development Division, Singapore Clinical Research Institute, Biopolis, Singapore.
Acta Paediatr. 2010 Nov;99(11):1719-23. doi: 10.1111/j.1651-2227.2009.01593.x.
To examine linear growth and its association with cognitive ability at age 11 years among full-term singletons with varying degree of stunting or without stunting at age 6 months.
A total of 1516 Filipino term-born singletons were followed bimonthly from age 6 to 24 months and took cognitive and academic achievement tests at 11 years. The tests were factor-analysed to give a summary cognitive ability score. Linear regression was used to examine associations and adjust for covariates.
Mean height-for-age Z-score (HAZ) was -1.0 at age 6 months and -2.4 at 24 months. HAZ at 6 months, change in HAZ from 6 to 24 months and change in HAZ from 24 months to 11 years were positively associated with cognitive ability at 11 years (each p < 0.001). The association was seen in all categories of HAZ at 6 months.
In this setting where linear growth retardation was common, association between linear growth after age 6 months and cognitive ability in adolescence was not dependent on initial HAZ. Prevention of growth stunting may benefit all children regardless of their initial HAZ.
研究 6 个月时存在不同程度生长迟缓或无生长迟缓的足月单胎婴儿，其线性生长及其与 11 岁时认知能力的关系。
1516 名菲律宾足月出生的单胎婴儿从 6 月龄起每 2 个月随访一次，至 24 月龄，11 岁时进行认知和学业成绩测试。采用因子分析法得出综合认知能力评分。采用线性回归分析来检验关联，并调整协变量。
6 月龄时身高别年龄 Z 评分（HAZ）的平均值为-1.0，24 月龄时为-2.4。6 月龄时的 HAZ、6 至 24 月龄 HAZ 的变化以及 24 至 11 岁 HAZ 的变化与 11 岁时的认知能力呈正相关（均 p<0.001）。这种相关性在 6 月龄时的所有 HAZ 类别中均可见。
在这种线性生长迟缓普遍存在的情况下，6 个月后线性生长与青春期认知能力之间的关联并不依赖于初始 HAZ。预防生长迟缓可能使所有儿童受益，而与他们的初始 HAZ 无关。
