Department of Urology, RWTH University Aachen, Aachen, Germany.
BJU Int. 2010 Feb;105(3):309-12. doi: 10.1111/j.1464-410X.2009.09077.x. Epub 2009 Nov 13.
The application of stem cells and their use in tissue-engineering approaches is emerging in clinical therapeutic intervention strategies. The use of adult stem cells, either autologous or allogenic, does not raise ethical concerns, in contrast to embryonic stem cells. Mesenchymal stromal cells (MSCs) can be easily obtained from bone marrow or from adipose tissue and further expanded in vitro. Due to their differentiation capacity, MSCs are very attractive for tissue engineering purposes. Furthermore, MSCs secrete a variety of mediators that have beneficial effects on the regenerating tissue. In this review we give an insight into stem cell hierarchy, define the properties of MSCs and summarize recent reports of their administration in urological diseases.
干细胞的应用及其在组织工程方法中的应用正在临床治疗干预策略中出现。与胚胎干细胞不同，使用自体或同种异体的成体干细胞不会引起伦理问题。间充质基质细胞 (MSCs) 可以从骨髓或脂肪组织中轻易获得，并在体外进一步扩增。由于其分化能力，MSCs 非常适合组织工程目的。此外，MSCs 分泌多种对再生组织具有有益作用的介质。在这篇综述中，我们深入了解了干细胞的层次结构，定义了 MSCs 的特性，并总结了最近关于它们在泌尿系统疾病中的应用的报告。
