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枕神经阻滞:症状药物治疗的效果:过度使用和头痛类型对失败率的影响。

Occipital nerve blocks: effect of symptomatic medication: overuse and headache type on failure rate.

机构信息

21st Century Neurology, 2601 North 3rd St.#125, Phoenix, AZ 85004, USA.

出版信息

Headache. 2009 Nov-Dec;49(10):1479-85. doi: 10.1111/j.1526-4610.2009.01549.x.

Abstract

OBJECTIVE

To explore the effect of symptomatic medication overuse (SMO) and headache type on occipital nerve block (ONB) efficacy.

METHODS

We conducted a chart review of all of the ONBs performed in our clinic over a 2-year period.

RESULTS

Of 108 ONBs with follow-up data, ONB failed in 22% of injections overall. Of the other 78%, the mean decrease in head pain was 83%, and the benefit lasted a mean of 6.6 weeks. Failure rate without SMO was 16% overall, and with SMO was 44% overall (P < .000). In those who did respond, overall magnitude and duration of response did not differ between those with and those without SMO. Without SMO, ONB failure rate was 0% for postconcussive syndrome, 14% for occipital neuralgia, 11% for non-intractable migraine, and 39% for intractable migraine. With SMO, failure rate increased by 24% (P = .14) in occipital neuralgia, by 36% (P = .08) for all migraine, and by 52% (P = .04) for non-intractable migraine.

CONCLUSIONS

SMO tripled the risk of ONB failure, possibly because medication overuse headache does not respond to ONB. SMO increased ONB failure rate more in migraineurs than in those with occipital neuralgia, possibly because migraineurs are particularly susceptible to medication overuse headache. This effect was much more pronounced in non-intractable migraineurs than in intractable migraineurs.

摘要

目的

探讨症状性药物过度使用(SMO)和头痛类型对枕神经阻滞(ONB)疗效的影响。

方法

我们对 2 年内我们诊所进行的所有 ONB 进行了图表回顾。

结果

在 108 例有随访数据的 ONB 中,整体注射的 ONB 失败率为 22%。在其余 78%的病例中,头痛缓解的平均幅度为 83%,获益平均持续 6.6 周。无 SMO 的失败率为总体的 16%,有 SMO 的失败率为总体的 44%(P<.000)。在有反应的患者中,有无 SMO 患者的总体反应幅度和持续时间没有差异。无 SMO 时,ONB 失败率为创伤后综合征 0%、枕神经痛 14%、非难治性偏头痛 11%、难治性偏头痛 39%。有 SMO 时,枕神经痛增加 24%(P=.14),所有偏头痛增加 36%(P=.08),非难治性偏头痛增加 52%(P=.04)。

结论

SMO 使 ONB 失败的风险增加了两倍,可能是因为药物过度使用性头痛对 ONB 无反应。SMO 使偏头痛患者的 ONB 失败率增加高于枕神经痛患者,可能是因为偏头痛患者特别容易发生药物过度使用性头痛。这种影响在非难治性偏头痛患者中比在难治性偏头痛患者中更为明显。

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