Neurology Department, Hospital Álvarez-Buylla, Mieres, Spain.
J Neuroimaging. 2011 Apr;21(2):e83-5. doi: 10.1111/j.1552-6569.2009.00438.x.
Cerebral amyloid angiopathy (CAA) might alter cerebral hemodynamics. Impairment of vasomotor reactivity may constitute a biomarker of amyloid angiopathy and therefore it may be useful to distinguish disorders with CAA from other conditions. The aim of this study was to assess the vasomotor reactivity in two conditions characterized by CAA: Alzheimer's disease and amyloid hemorrhage.
We assessed the vasomotor using transcranial Doppler and the breath-holding method.
Responses obtained in controls were higher than in patients with Alzheimer's or with antecedent of amyloid hemorrhage while there was no statistical difference in the comparison between these last two groups.
The vasomotor reactivity seems to be similarly impaired in Alzheimer's disease and amyloid hemorrhage patients.
脑淀粉样血管病（CAA）可能改变脑血流动力学。血管运动反应受损可能构成淀粉样血管病的生物标志物，因此区分 CAA 相关疾病和其他疾病可能很有用。本研究的目的是评估两种以 CAA 为特征的疾病的血管运动反应：阿尔茨海默病和淀粉样出血。
我们使用经颅多普勒超声和屏气法评估血管运动反应。
对照组获得的反应高于阿尔茨海默病或有淀粉样出血病史的患者，而这后两组之间的比较没有统计学差异。
阿尔茨海默病和淀粉样出血患者的血管运动反应似乎同样受损。
