Keage Hannah A D, Churches Owen F, Kohler Mark, Pomeroy Danielle, Luppino Rocco, Bartolo Michelle L, Elliott Scott
Cognitive Neuroscience Laboratory, School of Psychology, Social Work and Social Policy, Adelaide, S.A., Australia.
Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):258-70. doi: 10.1159/000339234. Epub 2012 Jun 29.
BACKGROUND/AIM: The contribution of cerebrovascular dysfunction to the manifestation of dementia and cognitive decline in late life is gaining increased attention. We aimed to systematically review evidence for associations between dementia or aging and cerebrovascular function as measured using transcranial Doppler (TCD) examination.
A total of 1,172 articles were retrieved from PsychInfo and PubMed searches, and 34 relevant articles were identified using a variety of TCD methods.
The pulsatility index (vessel resistance), spontaneous emboli and cerebrovascular reactivity to hyper-/hypocapnia appeared good discriminators of dementia. Aging was associated with a slowing in blood flow velocity.
TCD ultrasonography is inexpensive, portable and well tolerated by aged and demented subjects. The technique stands to make a valuable contribution to the knowledge regarding the underlying functional biology of age-related cognitive change and dementia.
背景/目的：脑血管功能障碍对老年痴呆症和认知衰退表现的影响日益受到关注。我们旨在系统回顾使用经颅多普勒（TCD）检查测量的痴呆症或衰老与脑血管功能之间关联的证据。
通过检索PsychInfo和PubMed共获取1172篇文章，并使用多种TCD方法确定了34篇相关文章。
搏动指数（血管阻力）、自发性栓子以及脑血管对高/低碳酸血症的反应似乎是痴呆症的良好判别指标。衰老与血流速度减慢有关。
TCD超声检查价格低廉、便于携带，老年和痴呆患者耐受性良好。该技术对于了解与年龄相关的认知变化和痴呆症潜在功能生物学方面的知识可能会做出有价值的贡献。
