Universidade Federal do Rio Grande do Sul (UFRGS)-Postgraduate Course in Medical Sciences, Porto Alegre, RS, Brazil.
J Sex Med. 2010 Apr;7(4 Pt 1):1529-37. doi: 10.1111/j.1743-6109.2009.01584.x. Epub 2009 Nov 12.
Although Peyronie's Disease (PD) was first described over 250 years ago, its precise etiology remains obscure.
Analyze a variety of potential associated factors with PD, including erectile dysfunction.
This cross-sectional study included 83 consecutive men with PD and 252 age-matched controls. All men completed the International Index of Erectile Function (IIEF) and were evaluated regarding their clinical and demographic characteristics, comorbidities, and used medications. Anthropometric measures included body mass index and waist circumference (WC). Fasting blood glucose, lipid profile, total testosterone, and dehydroepiandrosterone-sulfate were determined.
Clinical and laboratory characteristics associated to PD.
The mean age was 59.2 + or - 10 years in the cases and 59.7 + or - 12 years in the controls. Marital status, current smoking, and excessive consumption of alcoholic beverages were similar between groups (P > 0.05). PD was more common among white skin color males (P = 0.001). The mean score for each IIEF domain and the androgen levels were similar in the two groups. Thiazides were the only medication associated to PD (P = 0.03). Dupuytren's disease was more frequent among individuals with PD (P = 0.001). The distribution of all other comorbidities investigated was similar between groups (P > 0.05). The characteristics WC > 102 cm and levels of low-density lipoprotein (LDL) > 130 mg/dL were more prevalent in the controls (P < 0.05). After multivariate analysis, white skin color (OR: 8.47, 95%CI: 1.98-36.24) and thiazide use (OR: 2.29, 95%CI: 1.07-4.90) were associated to PD, and LDL > 130 mg/dL (OR: 0.55, 95%CI: 0.32-0.92) and WC > 102 cm (OR: 0.53, 95%CI: 0.29-0.96) were inversely associated to PD.
In this study, PD was more common among white skin colored males. An inverse relationship with the presence of elevated serum levels of LDL and WC was observed. We found no association with medications other than thiazides and comorbidities other than Dupuytren's disease. Androgen serum levels and sexual dysfunction had also no association to PD.
尽管 250 多年前就已经描述了佩罗尼氏病（PD），但其确切病因仍不清楚。
分析与 PD 相关的各种潜在因素，包括勃起功能障碍。
这项横断面研究包括 83 例连续的 PD 男性患者和 252 名年龄匹配的对照组。所有男性都完成了国际勃起功能指数（IIEF）问卷，并对其临床和人口统计学特征、合并症和使用药物进行了评估。人体测量学指标包括体重指数和腰围（WC）。检测空腹血糖、血脂谱、总睾酮和硫酸脱氢表雄酮。
与 PD 相关的临床和实验室特征。
病例组的平均年龄为 59.2 ± 10 岁，对照组为 59.7 ± 12 岁。两组之间的婚姻状况、当前吸烟和过量饮酒情况相似（P > 0.05）。PD 在白人男性中更为常见（P = 0.001）。两组间每个 IIEF 域的平均评分和雄激素水平相似。噻嗪类药物是唯一与 PD 相关的药物（P = 0.03）。PD 患者中更常见掌腱膜挛缩症（P = 0.001）。两组间调查的其他所有合并症的分布相似（P > 0.05）。WC > 102 cm 和 LDL > 130 mg/dL 的比例在对照组中更高（P < 0.05）。多变量分析后，白种人肤色（OR：8.47，95%CI：1.98-36.24）和噻嗪类药物使用（OR：2.29，95%CI：1.07-4.90）与 PD 相关，而 LDL > 130 mg/dL（OR：0.55，95%CI：0.32-0.92）和 WC > 102 cm（OR：0.53，95%CI：0.29-0.96）与 PD 呈负相关。
在这项研究中，PD 在白种人男性中更为常见。血清 LDL 水平升高和 WC 升高与 PD 呈负相关。我们发现除了噻嗪类药物和掌腱膜挛缩症之外，与其他药物或其他合并症均无关联。雄激素水平和性功能障碍与 PD 也无关联。
