Department of Urology, Yamaguchi University School of Medicine, Department of Urology, UBE Industries Central Hospital, Ube, Yamaguchi, Japan.
J Sex Med. 2012 Oct;9(10):2716-23. doi: 10.1111/j.1743-6109.2012.02868.x. Epub 2012 Aug 15.
The incidence of Peyronie's disease (PD) in the general population is believed to be as high as 20%. However, most of the data concerning the prevalence of PD have been obtained from Caucasian populations.
The aim of this study was to examine the prevalence of PD in Asia and among men undergoing hemodialysis and discuss the pathophysiology of PD.
A total of 1,090 men who received a routine health check at our hospital (control group) as well as 130 male patients undergoing maintenance hemodialysis were enrolled. The diagnosis of PD was based on a palpable penile plaque.
Hemodialysis patients were asked about their sexual activity and completed the International Index of Erectile Function-5 questionnaires. The differences between patients' and hemodialysis-associated factors, comorbidities, and medications were statistically assessed for patients with and without PD.
The prevalence of PD was significantly increased among hemodialysis patients (12 patients: 9.2%) relative the control group (six men: 0.6%) (P<0.0001, odds ratio: 18.4). In both groups, the plaques were primarily allocated dorsally. In the hemodialysis patients with PD, the frequency of masturbation (P<0.05) and the incidence of moderate or severe erectile dysfunction (P<0.01) were significantly higher than those among hemodialysis patients without PD. In comparison with patients without PD, the number of acetate dialysate users was significantly higher among patients with PD (P<0.05), and none of the PD patients used angiotensin-related antihypertensive drugs (P<0.05).
The prevalence of PD in healthy Japanese men is low (0.6%), which suggests the existence of racial differences in the prevalence of PD. Moreover, these results indicate that hemodialysis increases the incidence of PD. The differences in the characteristics between male hemodialysis patients with and without PD provide new insights into the pathophysiology and therapeutic window of PD.
据信，普通人群中 Peyronie 病（PD）的发病率高达 20%。然而，大多数关于 PD 患病率的数据都是从白种人群中获得的。
本研究旨在检查亚洲人群中 PD 的患病率，并探讨 PD 的病理生理学。
共纳入 1090 名在我院接受常规健康检查的男性（对照组）和 130 名接受维持性血液透析的男性患者。PD 的诊断基于可触及的阴茎斑块。
询问血液透析患者的性行为，并完成国际勃起功能指数-5 问卷。对有和无 PD 的患者进行统计学评估，评估患者与血液透析相关的因素、合并症和药物之间的差异。
与对照组（6 名男性：0.6%）相比，血液透析患者 PD 的患病率明显升高（12 名患者：9.2%）（P<0.0001，优势比：18.4）。在两组中，斑块主要位于背部。在 PD 血液透析患者中，自慰频率（P<0.05）和中重度勃起功能障碍的发生率（P<0.01）明显高于无 PD 的血液透析患者。与无 PD 的患者相比，PD 患者中使用醋酸盐透析液的人数明显更多（P<0.05），且无 PD 患者使用血管紧张素相关降压药（P<0.05）。
健康日本男性 PD 的患病率较低（0.6%），这表明 PD 的患病率存在种族差异。此外，这些结果表明血液透析会增加 PD 的发病率。有和无 PD 的男性血液透析患者的特征差异为 PD 的病理生理学和治疗窗口提供了新的见解。
