The Rockefeller University, Laboratory of Neuroendocrinology, 1230 York Avenue, New York, New York 10021 USA.
Mol Cell Neurosci. 1992 Dec;3(6):529-35. doi: 10.1016/1044-7431(92)90065-a.
GAP-43 is expressed in axonal growth cones during development and regeneration. High levels of GAP-43 persist in the adult hippocampus, reflecting perhaps the ongoing neurogenesis and synaptic plasticity characteristic of this brain region. Since the morphology and survival of hippocampal neurons are altered by adrenal steroids and aging, we have investigated the effects of adrenalectomy and of aging on the expression of hippocampal GAP-43 mRNA, as a molecular marker for these events. Adrenalectomy for 7 days results in an increase in GAP-43 mRNA expression, as assessed by in situ hybridization, in the pyramidal cell layers of the hippocampus. Both male and female aged rats exhibit levels of GAP-43 mRNA in hippocampal pyramidal cells lower than those of their younger counterparts.
GAP-43 在发育和再生过程中表达于轴突生长锥。高水平的 GAP-43 持续存在于成年海马体中，这可能反映了该脑区持续的神经发生和突触可塑性。由于肾上腺类固醇和衰老会改变海马神经元的形态和存活，我们研究了肾上腺切除术和衰老对海马 GAP-43 mRNA 表达的影响，GAP-43 mRNA 是这些事件的分子标志物。通过原位杂交评估，7 天的肾上腺切除术导致海马锥体细胞层中的 GAP-43 mRNA 表达增加。雄性和雌性老年大鼠的海马锥体细胞中的 GAP-43 mRNA 水平均低于年轻大鼠。
