Vigneswara Vasanthy, Kundi Sarina, Ahmed Zubair
Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
J Signal Transduct. 2012;2012:361721. doi: 10.1155/2012/361721. Epub 2012 Jul 16.
The poor or lack of injured adult central nervous system (CNS) axon regeneration results in devastating consequences and poor functional recovery. The interplay between the intrinsic and extrinsic factors contributes to robust inhibition of axon regeneration of injured CNS neurons. The insufficient or lack of trophic support for injured neurons is considered as one of the major obstacles contributing to their failure to survive and regrow their axons after injury. In the CNS, many of the signalling pathways associated with neuronal survival and axon regeneration are regulated by several classes of receptor tyrosine kinases (RTK) that respond to a variety of ligands. This paper highlights and summarises the most relevant recent findings pertinent to different classes of the RTK family of molecules, with a particular focus on elucidating their role in CNS axon regeneration.
成年中枢神经系统（CNS）轴突再生能力差或缺乏会导致灾难性后果和功能恢复不佳。内在因素和外在因素之间的相互作用对损伤的中枢神经系统神经元轴突再生产生强烈抑制作用。对损伤神经元的营养支持不足或缺乏被认为是导致其在损伤后无法存活和轴突再生的主要障碍之一。在中枢神经系统中，许多与神经元存活和轴突再生相关的信号通路由几类受体酪氨酸激酶（RTK）调节，这些受体酪氨酸激酶对多种配体作出反应。本文重点介绍和总结了与不同类别的RTK分子家族最相关的最新研究发现，特别关注阐明它们在中枢神经系统轴突再生中的作用。
