Division of Gastroenterology, Department of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.
Gastroenterol Clin North Am. 2009 Dec;38(4):669-89. doi: 10.1016/j.gtc.2009.07.004.
This article describes the cancer risks of commonly used inflammatory bowel disease (IBD) medications, with an emphasis on hematologic malignancy risks. The increasing use of immunosuppressant therapies in the treatment of IBD has raised this question to an even greater importance. Studies evaluating these medications are complicated due to varying disease severity and concomitant use of other immunosuppressant medication. The potential risks of all therapies must be weighed against the benefits these therapies can offer these patients.
本文描述了常用的炎症性肠病 (IBD) 药物的癌症风险,重点介绍了血液系统恶性肿瘤的风险。IBD 治疗中免疫抑制剂治疗的应用日益增加,使这个问题变得更加重要。由于疾病严重程度不同以及同时使用其他免疫抑制剂药物,评估这些药物的研究变得复杂。必须权衡所有治疗方法的潜在风险与这些治疗方法为这些患者带来的益处。