Seattle Children's and University of Washington School of Medicine, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, 4800 Sand Point Way, NE, PO Box 5371/W-7830, Seattle, WA 98105, USA.
Expert Rev Gastroenterol Hepatol. 2009 Dec;3(6):681-91. doi: 10.1586/egh.09.53.
Hepatobiliary disease is not uncommon in patients with inflammatory bowel disease (IBD). The most common autoimmune hepatic associations are primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH). The immunosuppressant medications used in the treatment of IBD also have potential hepatotoxicity. PSC is most commonly associated with IBD, specifically ulcerative colitis. AIH, a more classic autoimmune disease diagnosed commonly in isolation of other conditions in the same individual, is less commonly associated with IBD. Additionally, a subgroup of patients have features of both PSC and AIH, termed overlap syndrome, that is also sometimes seen in IBD patients. This review will discuss the most common liver disease associations seen in patients with IBD: PSC, AIH and overlap syndrome. Additionally, the most common drug-related hepatotoxicities encountered when treating IBD will be reviewed.
肝胆疾病在炎症性肠病（IBD）患者中并不少见。最常见的自身免疫性肝相关性疾病是原发性硬化性胆管炎（PSC）和自身免疫性肝炎（AIH）。用于治疗 IBD 的免疫抑制剂药物也具有潜在的肝毒性。PSC 最常与 IBD 相关，特别是溃疡性结肠炎。AIH 是一种更典型的自身免疫性疾病，通常在同一患者中与其他疾病分离诊断，与 IBD 的相关性较低。此外，一部分患者具有 PSC 和 AIH 的特征，称为重叠综合征，也可见于 IBD 患者。本文将讨论在 IBD 患者中最常见的肝脏疾病相关性疾病：PSC、AIH 和重叠综合征。此外，还将回顾治疗 IBD 时最常见的药物相关性肝毒性。
