Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Trends Biochem Sci. 2010 Apr;35(4):236-45. doi: 10.1016/j.tibs.2009.10.003. Epub 2009 Nov 11.
Mucins are high molecular weight glycoproteins that are involved in regulating diverse cellular activities both in normal and pathological conditions. Mucin activity and localization is mediated by several molecular mechanisms, including discrete interactions with other proteins. An understanding of the biochemistry behind the known interactions between mucins and other proteins, coupled with an appreciation of their pathophysiological significance, can lend insight into the development of novel therapeutic agents. Indeed, a recent study demonstrated that a cell permeable inhibitor, PMIP, that disrupts the MUC1-EGFR interaction, is effective in killing breast cancer cells in vitro and in tumor models.
黏蛋白是高分子量糖蛋白，参与调节正常和病理条件下的多种细胞活动。黏蛋白的活性和定位由几种分子机制介导，包括与其他蛋白质的离散相互作用。了解已知的黏蛋白与其他蛋白质之间相互作用的生物化学基础，以及对其病理生理意义的认识，可以深入了解新型治疗剂的开发。事实上，最近的一项研究表明，一种细胞渗透性抑制剂 PMIP，可破坏 MUC1-EGFR 相互作用，在体外和肿瘤模型中有效杀死乳腺癌细胞。
