Bidram Maryam, Ganjalikhany Mohamad Reza
Department of Cell and Molecular Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Heliyon. 2024 Nov 22;10(23):e40563. doi: 10.1016/j.heliyon.2024.e40563. eCollection 2024 Dec 15.
Cancer is known as the main cause of mortality in the world, and every year, the rate of incidence and death due to cancer is increasing. Bioactive peptides are one of the novel therapeutic options that are considered a suitable alternative to toxic chemotherapy drugs because they limit side effects with their specific function. In fact, bioactive peptides are short amino acid sequences that obtain diverse physiological functions to maintain human health after being released from parent proteins. This group of biological molecules that can be isolated from different types of natural protein sources has attracted much attention in the field of pharmaceutical and functional foods production. The current article describes the therapeutic benefits of bioactive peptides and specifically and extensively reviews their role in cancer treatment, available sources for discovering anticancer peptides, mechanisms of action, production methods, and existing challenges.
癌症被认为是全球主要的死亡原因，并且每年因癌症导致的发病率和死亡率都在上升。生物活性肽是新型治疗选择之一，由于其特定功能限制了副作用，因此被视为有毒化疗药物的合适替代品。事实上，生物活性肽是短氨基酸序列，从母体蛋白质释放后获得多种生理功能以维持人类健康。这组可从不同类型天然蛋白质来源分离的生物分子在药物和功能性食品生产领域引起了广泛关注。本文介绍了生物活性肽的治疗益处，并具体且广泛地综述了它们在癌症治疗中的作用、发现抗癌肽的可用来源、作用机制、生产方法以及现存挑战。
